PUBLICATIONS
Metabolic diversity in commensal protists regulates intestinal immunity and transkingdom competition. Cell
Elias R. Gerrick, Soumaya Zlitni, Patrick T. West, Matthew M. Carter, Claire M. Mechler, Matthew R. Olm, Elisa B. Caffrey, Jessica A. Li, Steven K. Higginbottom, Christopher J. Severyn, Frauke Kracke, Alfred M. Spormann, Justin L. Sonnenbug, Ami S. Bhatt, Michael R. Howitt. 2024, doi:10.1016/j.cell.2023.11.018.
Commensal protists in reptiles display flexible host range and adaptation to ectothermic hosts. mBio
Elias R. Gerrick, Leila B. DeSchepper, Claire M. Mechler, Lydia-Marie Joubert, Freeland Dunker, Timothy J. Colston, Michael R. Howitt. 2023, doi: 10.1128/mbio.02273-23.
Tuft cells mediate commensal remodeling of the small intestinal antimicrobial landscape. PNAS
Connie Fung, Lisa M. Fraser, Gabriel M. Barrón, Matthew B. Gologorsky, Samantha N. Atkinson, Elias R. Gerrick, Michael Hayward, Jennifer Ziegelbauer, Jessica A. Li, Katherine F. Nico, Miles D. W. Tyner, Leila B. DeSchepper, Amy Pan, Nita H. Salzman, Michael R. Howitt. 2023, 120(23), e2216908120. doi:10.1073/pnas.2216908120.
The abundance and morphology of human large intestinal goblet and tuft cells during chronic schistosomiasis. Parasite Immunology
Matthew B. Gologorsky, Claire M. Mechler, Erna Forgó, Gregory W. Charville, Michael R. Howitt. 2023, e12981. doi:10.1111/pim.12981.
Succinate and tuft cells: How does this sensory process interface with food allergy? Journal of Allergy and Clinical Immunology
Katherine F. Nico, Miles D. W. Tyner, Michael R. Howitt. 2022, 150(3), 580-582.
A Tuft Act to Follow: Leukotrienes Take the Stage in Anti-worm Immunity. Immunity
Connie Fung, Michael R. Howitt. 2020, 52(3), 426-428.
The Taste Receptor TAS1R3 Regulates Small Intestinal Tuft Cell Homeostasis. Immunohorizons
Michael R. Howitt, Y. Grace Cao, Matthew B. Gologorsky, Jessica A. Li, Adam L. Haber, Moshe Biton, Jessica Lang, Monia Michaud, Aviv Regev and Wendy S. Garrett. 2020, 4 (1) 23-32
Tropism for tuft cells determines immune promotion of norovirus pathogenesis. Science
Wilen, C. B., Lee, S., Hsieh, L. L., Orchard, R. C., Desai, C., Hykes, B. L., McAllaster, M. R., Balce, D. R., Feehley, T., Brestoff, J. R., Hickey, C. A., Yokoyama, C. C., Wang, Y. T., MacDuff, D. A., Kreamalmayer, D., Howitt, M. R., Neil, J. A., Cadwell, K., Allen, P. M., Handley, S. A., van Lookeren Campagne, M., Baldridge, M. T., Virgin, H. W. 2018; 360 (6385): 204–8
A single-cell survey of the small intestinal epithelium. Nature
Haber, A. L., Biton, M., Rogel, N., Herbst, R. H., Shekhar, K., Smillie, C., Burgin, G., Delorey, T. M., Howitt, M. R., Katz, Y., Tirosh, I., Beyaz, S., Dionne, D., Zhang, M., Raychowdhury, R., Garrett, W. S., Rozenblatt-Rosen, O., Shi, H. N., Yilmaz, O., Xavier, R. J., Regev, A. 2017; 551 (7680): 333–39
Tuft cells, taste-chemosensory cells, orchestrate parasite type 2 immunity in the gut. Science
Howitt, M. R., Lavoie, S., Michaud, M., Blum, A. M., Tran, S. V., Weinstock, J. V., Gallini, C. A., Redding, K., Margolskee, R. F., Osborne, L. C., Artis, D., Garrett, W. S. 2016; 351 (6279): 1329-1333
Helicobacter pylori CheZHP and ChePep form a novel chemotaxis-regulatory complex distinct from the core chemotaxis signaling proteins and the flagellar motor. Molecular microbiology
Lertsethtakarn, P., Howitt, M. R., Castellon, J., Amieva, M. R., Ottemann, K. M. 2015; 97 (6): 1063-1078
The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T-reg Cell Homeostasis. Science
Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., Garrett, W. S. 2013; 341 (6145): 569-573
Exploring host-microbiota interactions in animal models and humans. Genes & Development
Kostic, A. D., Howitt, M. R., Garrett, W. S.
A complex microworld in the gut: Gut microbiota and cardiovascular disease connectivity. Nature Medicine
Howitt, M. R., Garrett, W. S. 2012; 18 (8): 1188-1189
ChePep Controls Helicobacter pylori Infection of the Gastric Glands and Chemotaxis in the Epsilonproteobacteria. mBio
Howitt, M. R., Lee, J. Y., Lertsethtakarn, P., Vogelmann, R., Joubert, L., Ottemann, K. M., Amieva, M. R. 2011; 2 (4)